Strategies demonstrate a connection between PDE3B and OPNas well as a roleįor protein kinase CK2 inpancreatic β-cells. In summary, results from using a number of In the presence ofįorskolin, PDE inhibitors, insulin, or a protein kinase CK2 inhibitor, similar alterations in protein levels Under conditions of relevance for insulin secretion. We studied PDE3B and OPN proteins and, in A lot of Apps are available for various kinds of problem domains, including bioinformatics, social network analysis, and semantic web. You can use the ArcGIS platform to apply geography to solving problems and making. Cytoscape is an open source software platform for visualizing complex networks and integrating these with any type of attribute data. Furthermore, OPN interacts with protein kinase CK2 ina distinct submodule of the Cytoscape core distribution provides a basic set of features for data. InĪddition, in silico analysis shows that PDE3B and OPN are Manner in islets from RIP-PDE3B mice, as compared to wild-type islets. We show that osteopontin (OPN) mRNA is increased in a dose-dependent (PDE3B) and dysregulated insulin secretion, were subjected to microarrayĪnalysis. RIP-PDE3B mice, exhibiting β-cell specific overexpression of the cAMP/cGMP-degrading enzyme phosphodiesterase 3B Journal of Biomedical Science and Engineering, Manganiello, Lena Stenson, Eva Degermanĭiabetes Mellitus Pancreatic Islets β-Cells cAMP Cyclic Nucleotide Phosphodiesterases PDE Osteopontin Protein Kinase CK2 doi:10.1093/bioinformatics/btq675Ĭyclic nucleotide phosphodiesterase 3B is connected to osteopontin and protein kinase CK2 in pancreatic β-cellsĪUTHORS: Emilia Heimann, Amitabh Sharma, Nalini Raghavachari, Vincent C. (2011) Cytoscape 2.8: New features for data integration and network visualization.
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